Insulin comes in short-acting, long-acting and mixed formulations. Humalog is a rapid-acting insulin meant to cover a meal being eaten. Lantus is a long-acting insulin intended to provide coverage throughout the day.
Purified human insulin is most commonly used, however, insulin from beef and pork sources also are available. Insulin may be given as an injection of a single dose of one type of insulin once a day. Different types of insulin can be mixed
There is not one answer for this because different formulations of insulin will reach peak levels at different times and the length of time that insulin stays active will vary because of anti-bodies to inusulin as well as metabolic factors. Having said that human insulin takes about an hour to peak and then is about half that peak within 5 hours. see http://care.diabetesjournals.org/content/7/2/188.full.pdf
Yes, insulin contains zinc. In its crystalline form, insulin is often complexed with zinc ions, which help stabilize its structure and influence its pharmacokinetics. This is particularly relevant for certain formulations of insulin used in diabetes management, as zinc can affect the rate of insulin release into the bloodstream.
It is usually human insulin precipitated with protamin (a fish protein) to reduce its solubility and increase its duration of action. The formulations also contain cresol, phenol , Zn and sodium phosphate as a buffer.
Disodium phosphate dihydrate is used as a buffering agent in insulin formulations to maintain the pH of the solution. It helps stabilize the insulin and prevent degradation. Additionally, disodium phosphate dihydrate can also help improve the solubility and stability of insulin during storage.
Insulins that come in suspension form include NPH (Neutral Protamine Hagedorn) insulin and certain mixtures like 70/30, which contains 70% NPH and 30% regular insulin. These suspensions require gentle mixing before injection to ensure proper dosing, as the insulin particles can settle over time. Other insulin formulations, such as long-acting insulins like insulin glargine or insulin detemir, are typically not in suspension form.
Yes, there are generic formulations of HUMULIN, which is a brand of human insulin used to manage diabetes. Generic versions are typically available for various types of insulin, including regular and NPH insulin, under different names. These generics are considered therapeutically equivalent to the brand-name product, providing the same efficacy and safety profile. However, it's important for patients to consult their healthcare provider before switching to a generic version.
It is not recommended to mix Novolog and Novolin N insulin together in the same syringe due to differences in their onset and duration of action. These two insulin types have different formulations and mixing them can affect their efficacy and lead to unpredictable blood sugar control. It is best to consult with a healthcare provider for guidance on how to properly administer these insulins if needed.
Insulin is typically measured in units rather than volume. In the context of U-100 insulin, which is the most common concentration, there are 100 units of insulin per 1 mL (or 1 cc). Therefore, 1 cc of U-100 insulin contains 100 units of insulin. Different concentrations of insulin may have different unit-to-volume ratios.
Before the advent of genetic engineering methods of producing Insulin, the hormone was directly isolated from Cows and Pigs. There was no other option of obtaining these hormones. Once they were isolates from these animals, the went through a crude purification process before being bottled.
The most prominent brands of diabetes insulin today are synthetic brands of insulin. Some examples of synthetic insulin brands are Humulin and Novolin. http://www.drugstore.com/ask/what-are-the-different-types-of-insulin/qxa1685
The human insulin protein is composed of 51 amino acids, and has a molecular mass of 5808 Da. Insulin for other species will be somewhat different.