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what is A change in just one DNA base for the gene that codes for the protein causes sickle shaped red blood cells?
A change in just one DNA base in the gene that codes for the protein hemoglobin can lead to sickle cell disease. This specific mutation substitutes adenine for thymine in the gene, resulting in the production of abnormal hemoglobin called hemoglobin S. The altered hemoglobin causes red blood cells to assume a rigid, sickle shape, leading to various complications, including reduced oxygen transport and increased risk of blockages in blood vessels. This single base change exemplifies how small genetic variations can have significant effects on health.
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What is glutamate replaced by in sickle cell anemia?
In sickle cell anemia, glutamic acid is replaced by valine due to a single base change in the gene that codes for hemoglobin. This substitution causes the hemoglobin protein to form abnormal sickle-shaped red blood cells, leading to the symptoms of the disease.
What is the causative agent of sickle cell?
Sickle cell disease is caused by a mutation in the gene that encodes for hemoglobin, a protein in red blood cells that carries oxygen. This mutation results in the production of abnormal hemoglobin known as hemoglobin S, which causes red blood cells to become sickle-shaped and less flexible.
What is a genetic disorder that causes abnormal hemoglobin?
Sickle cell anemia causes sickle-shaped red blood cells. It is caused by a single base pair gene mutation.
Why is the sickle cell disease named that?
Because the condition causes the red blood cells to become sickle shaped rather than round.
Can you Describe how the amino acids changes in the protein affect the function of the protein and how this causes disease?
Changes in amino acids can alter the protein's structure, affecting its function by disrupting its binding sites or enzyme activity, leading to disease. For example, in sickle cell anemia, a single amino acid change in hemoglobin causes it to form abnormal-shaped red blood cells, affecting oxygen transport and leading to the disease's symptoms.
Is sickle cell anemia a type of poikilocytosis?
Yes, sickle cell anemia is a type of poikilocytosis, which is a condition characterized by the presence of abnormally shaped red blood cells in the bloodstream. In sickle cell anemia, the red blood cells are crescent or sickle-shaped due to a genetic mutation in the hemoglobin protein.
The mutation that results in sickle cell anemia produces effects that are?
The mutation that causes sickle cell anemia leads to the production of abnormal hemoglobin, which causes red blood cells to become sickle-shaped. These sickle-shaped cells can block blood vessels, impairing blood flow and leading to episodes of pain, tissue damage, and increased risk of infections.
A change in one nucleotide produces a different form of hemoglobin in some people which condition results from this change?
The change in one nucleotide that produces a different form of hemoglobin is known as sickle cell mutation, leading to the condition called sickle cell anemia. This genetic disorder causes red blood cells to become rigid and sickle-shaped, leading to various complications such as blockages in blood vessels, anemia, and organ damage.
What diseases arises from an amino acid change in protein hemoglobin?
sickle cell disease
What is the compared shape of a red blood cell to that of a sickle cell?
The red blood cells have a sickle shape, hence the name. They receive this shape from a protein in normal blood cells that is mutated. They carry less blood and block veins and capillaries easily.
What are abnormal crescent shaped BLOOD cell?
Abnormal crescent-shaped blood cells are known as sickle cells, which are characteristic of sickle cell disease. This genetic condition causes red blood cells to become rigid and curved, leading to blockages in blood vessels and reduced oxygen delivery to tissues. Sickle cell disease can result in pain, organ damage, and other serious complications.
Is Sickle-cell disease an example of an inherited mistake in the amino acid sequence?
Yes, sickle-cell disease is caused by a genetic mutation in the hemoglobin gene, resulting in an error in the amino acid sequence of the hemoglobin protein. This mistake leads to the production of abnormal hemoglobin that causes red blood cells to become sickle-shaped, leading to various health problems.
