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Known common side effects of oxycodone include:

Constipation; dizziness; drowsiness; headache; nausea; sleeplessness; vomiting; weakness. (none of which is directly heart related)

More severe possible side effects include:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating; fast or slow heartbeat; seizures; severe dizziness, lightheadedness, or fainting; slowed or difficult breathing; tremor; vision changes.

Bradycardia (resting heart rate of under 60 beats per minute - which, if it continues to drop can lead to cardiac arrest) has been observed in individuals who receive high doses, overdoses, or in patients not tolerant to opiates.

Individuals who take oxycodone and then also consume alcohol are at risk of severe central nervous system depression - which can include cardiac arrest.

Oxycodone can also aggravate existing cardiac problems.

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