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Taking Xanax with some antihistamines (which are in Nyquil) can result in excessive tiredness, excessive depression, breathing difficulties, and other related symptoms. But you can call an all night pharmacy (if you need to know ASAP) to see if the antihistamines in Nyquil will cause these problems if taken with Xanax. And it doesn't have to be a pharmacy that you use; they are usually good about answering questions like this even for non-customers.

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17y ago

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