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"Yes! Alcohol depletes your DHA, fish oil gives it back. If anything, if you drink alcohol, you SHOULD take fish oil!"

No, not a good idea. They both act as blood thinners and use the liver for metabolism via the cytochrome P450 pathway. This can potentially increase the load on your liver. Although random studies have shown fish oil to lower cholesterol and triglycerides, the possibility of nulling the benefits of fish oil could increase with alcohol consumption and increase overall liver enzymes, a primary indicator of liver injury. Here is an animal study on the effects of ethanol and fish oil combined. although a rat study, it should give a pretty clear indicator of the risks involved:

Rats were fed ethanol in combination with fish oil or a corn diet in order to evaluate the effect of fish oil feeding on liver injury, microsomal ethanol oxidation, and NADPH-dependent lipid peroxidation. The rats were maintained on the dietary regimen for 72 days, and for comparison, pair-fed controls were studied. The liver pathology score progressively worsened in rats fed alcohol, both in combination with fish oil and corn oil, but the severity of inflammation and focal fibrosis was greater in the ethanol fish oil fed rats as compared with the ethanol corn oil group, whereas the fatty change was greater in the ethanol corn oil fed rats. The alcohol treatment caused a 2-fold increase of the liver microsomal P450 content, and about a similar increase in the rate of microsomal NADPH oxidation. The amount of ethanol-inducible CYP2E1 was about 10-fold higher in alcohol-fed rats as compared with pair-fed controls. The NADPH-dependent lipid peroxidation in liver microsomes was about 10-fold higher in microsomes from alcohol-treated rats fed corn oil as compared with controls, but only 2- to 3-fold higher in alcohol-fed rats receiving fish oil than in pair-fed controls. This was due to a higher rate of NADPH-dependent lipid peroxidation in the control rats receiving fish oil. There was a pronounced correlation between the amount of CYP2E1 and the microsomal NADPH peroxidation in variously treated rats, and between the 2E1 levels and the pathology score. The data suggest that fish oil diet, like corn oil, supports ethanol-induced liver injury which is related to CYP2E1 induction and the presence of polyunsaturated fatty acids in the diet (i.e., either n-6 or n-3).

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12y ago
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Wiki User

13y ago

nope because it will cause spots

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