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Absolutely - the two are often prescribed together as part of an opiate patient's pain management therapy, with the Fentanyl Patch being the primary pain med, and the Oxycodone (usually Percocet, but it can be just Oxycodone or Oxy ER) as the breakthrough medication.

Initial patch dose estimates are always skewed toward the low end, and as a result, the initial dose usually isn't enough. That's why Percocet (oxycodone/tylenol combination) is usually prescribed at the outset. After the patch dose is nailed down. Percocet or Oxycodone is still prescribed as the breakthrough med for when the patient's activity raises pain levels to the point where it's exceeding the patch pain relief ability.

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