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It is unwise to begin mixing hydrocodone/APAP with any form of Excedrin, because they both contain acetaminophen. It it has been four to six hours after you have taken Excedrin, then you are following the instructions on the label and are not in any danger.

Excedrin contains 250mg of acetapinophen per pill.

Hydrocodone/APAP can contain anywhere from 325-750mg per pill. The most commonly prescribed dose has 500mg of acetaminophen in it.

You should not take more than 4000mg of acetaminophen in a day. If you are taking it daily, you should not take more than 3000mg. Per dose, you should not take more than 1000mg.

So, how unsafe it is depends on how much you have taken of each medication.

Always read the label, because many, many over the counter medications contain acetaminophen.

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16y ago

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