Can you take Benadryl with oxycodone?

Answer 1

Yes you can take them together, however Beandyl {diphenhydramine hydrochloride} can and usually will potentiate the opiates. That is to say will make Vicodins effects more pronounced, but as a side benefit it will help relieve the itching that Vicodin and other opiates can cause.If you don't mind the sleepiness the Benadryl will most likely cause and are careful not to drive, fall down or otherwise harm yourself because you are more messed up than with the Vicodin alone you can take them both. Improved Answer Actually, antihistaminics don't make opiates more powerful... there is NO action on pain receptor. The only "additive" effect might be on the drowsiness caused by both drugs. If you have itching from Vicodin, you'll get more benefit by switching to another opiate. Benadryl will only relieve in part the itching, and causing more drowsiness.