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According to the literature, there is no interaction between the two drugs. However, after you stop smoking, the doses of any medications you are using may need to be adjusted. Tell your doctor about all other medicines you use, especially insulin, blood thinners, or theophylline (Respid, Theobid, Theoclear, Theo-Dur or Uniphyl). Since smoking cessation causes a drop in dopamine levels, it might be necessary to adjust your anti-depressant dosage as well.

Personal experience: Cymbalta 60mg and Chantix caused Serotonin Syndrome.

It is advised you lowering/weening your Cymbalta by 50% prior to starting Chantix. As stated above in bold.

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