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It's generally not recommended to take NyQuil with Flexeril (cyclobenzaprine) and Celebrex (celecoxib) without consulting a healthcare provider first. Both NyQuil and Flexeril can cause drowsiness, which may be compounded when taken together, increasing the risk of sedation. Additionally, combining multiple medications can lead to potential interactions or side effects. Always consult a doctor or pharmacist before mixing medications.
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