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Yes.

Tylenol ES (extra strength) is an OTC pain reliever/fever reducer.

Hydrocodone is an opioid pain reliever available only by Rx.

You'll notice that on your bottle it will say Hydrocone/APAP. APAP is the abbreviation for Tylenol (Acetaminophen) so don't take additional Tylenol if you're taking the Hydrocone, which can wreack havoc on your liver.

Don't confuse OTC Tylenol with the #'s. Tylenol #1, #2, #3, #4, & #5 all contain codeine and caffeine in addition to the acetaminophen.

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