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Several products contain both, so it would seem safe to assume "yes". The caution lies in being careful not to mix combination medications which may each contain the same or similar medications, leading to the risk of overdose. Always read your labels carefully, and if you have any question whatsoever, so not hesitate to ask your doctor or licensed pharmacist.

Examples:

Theraflu® Cold & Cough (containing Dextromethorphan, Pheniramine, Phenylephrine) Zotex® (containing Dextromethorphan, Guaifenesin, Phenylephrine)

Zicam® Cough Plus D (containing Dextromethorphan, Phenylephrine)

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