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Benadryl and amitriptyline in combination are capable of blocking acetylcholine receptor activity. Possible side effects may include, but are not limited to, dry mouth, dry eyes, blurred vision, urinary retention, and constipation. Caution is warranted.

Also both these drugs are central nervous system depressants and the use of these two drugs together should be monitored. Some side effects may include, but are not limited to, ataxia, confusion, drowsiness, respiratory depression, and weakness. Since both medications have the potential to depress CNS function it is important to recognize that the risk of unwanted effects may increase with such use.

Amitriptyline may decrease the metabolism of Benadryl. This can alter Benadryls intended use. The benefits of combined use of these two medications usually outweigh the risks. Timing and dosage play a factor in the interaction of the two. You should talk to your doctor if you have any concerns of the above interactions.

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15y ago

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