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Yes, amoxicillin is understood to be safe to use with methadone (dolophine), but ALWAYS consult your physician and your pharmacist before taking any kind of prescription medication(s).

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An important side note for methadone managed patients in regard to the concomitant use of a different antibiotic medication, ciprofloxacin (Cipro) and methadone:

The concomitant use of methadone and ciprofloxacin is highly discouraged due to the increased risk of adverse effects of methadone (equating to methadone overdose).

Reason:

Inhibition of the enzymes that metabolize methadone (dolophine), i.e., CYP3A4 and/or CYP1A2 -- Ref: Eap et al. 2002; Herrlin et al. 2000.

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