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No. Neither contain appetite suppressants and in fact, taking both or either on an empty stomach will cause nausea, sometimes sever nausea depending on how empty the stomach is and the individual. Continuing to regularly take acetaminophen (aspirin) without food can cause stomach ulcers and damage the lining of the stomach.

It just doesn't work.

Added: Just wanted to make a quick, but important note: acetaminophen is NOT the same as aspirin, as it might be concluded from the answer above. In fact, acetaminophen (Tylenol) is a NON-ASPIRIN pain reliever that may be taken by people who cannot/should not take blood-thinning substances, such as aspirin.

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