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Co-administration of a prodrug with phenobarbital could result in altered metabolism of the prodrug, potentially enhancing or reducing its therapeutic effects. Phenobarbital is an enzyme inducer that may accelerate the conversion of the prodrug into its active form, leading to increased efficacy or toxicity. Additionally, the interaction may affect the pharmacokinetics of other concomitantly administered drugs. Monitoring for altered drug levels and therapeutic outcomes is advisable in such scenarios.

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