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First signs of toxicity are-anorexia,nausea and vomiting

CNS-headache,drowsiness,facial pain and depression

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13y ago

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Why does amlodipine interact with digoxin?

Amlodipine can interact with digoxin primarily due to its effects on the body's metabolism and cardiovascular system. Amlodipine may increase the plasma concentration of digoxin by affecting renal clearance and altering hemodynamics, potentially leading to digoxin toxicity. Additionally, both medications impact heart rate and contractility, which can compound their effects and increase the risk of adverse reactions. Therefore, careful monitoring is essential when these drugs are used together.


Is digoxin have a black box warning?

Yes, digoxin does have a black box warning. It is primarily associated with the risk of toxicity, particularly in patients with renal impairment or those who are elderly. The warning emphasizes the importance of monitoring serum digoxin levels and assessing renal function to minimize the risk of adverse effects. Additionally, it highlights the potential for digoxin to cause serious arrhythmias in susceptible individuals.


What labs to check when on Digoxin?

When a patient is on digoxin, it is important to monitor serum digoxin levels to ensure they are within the therapeutic range, typically between 0.5 and 2.0 ng/mL. Additionally, electrolyte levels, particularly potassium, magnesium, and calcium, should be checked, as imbalances can increase the risk of digoxin toxicity. Renal function tests, such as serum creatinine, are also crucial, as digoxin is primarily excreted by the kidneys. Regular monitoring helps to prevent adverse effects and ensure effective dosing.


When would you withhold digoxin or linoxon?

The rule of thumb is 'Nausea'. When the patient feels like vomiting, he may be getting overdose of digoxin. Otherwise, there may be hypokalemia or low level of potassium. Most common cause for the same is no food intake or loose motion. If you continue to give digoxin, patient will go for vomiting. Natures way to get rid of digoxin. if you continue to give digoxin, you have serious side effects, like digoxin induced cardiac arrhythmias.


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The most common adverse effects are gastrointestinal problems, including flatulence, diarrhea, and abdominal pain.


What are the side effects of alpha-glucosidase inhibitors?

The most common adverse effects are gastrointestinal problems, including flatulence, diarrhea, and abdominal pain.


Does adverse effects mean positive effects?

No, adverse effects do not mean positive effects. Adverse effects refer to harmful or unintended consequences resulting from a treatment, medication, or intervention, while positive effects indicate beneficial outcomes. The two terms are fundamentally oppositional, with adverse effects highlighting negative impacts.


How does the hypokalemia affect the effects of Digitalis?

Hypokalemia potentiates the effects of digoxin. Hypokalemia reduces the drive of the Na-K-ATPase, resulting in increased cellular Na in cardiac muscles. Digoxin does the same thing by blocking the Na-K-ATPase.


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What electrolyte is used to counteract digoxin?

Potassium is commonly used to counteract the effects of digoxin toxicity. Digoxin can cause low potassium levels, which can lead to dangerous heart rhythm abnormalities. Replenishing potassium levels can help reduce the risk of these complications.


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