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Ethanol (ethyl alcohol) affects many areas of the brain.

However, the most pronounced impact is found in the cerebrum, hippocampus, and cerebellum.

Ethanol affects the GABA (gamma-aminobutyric acid) neurotransmitter system, binding to GABA-A and GABA-B receptors, and increasing their ability to hyperpolarize neuronal cell membranes. So, it inhibits (slows, reduces) brain activity.

When this happens in the cerebral cortex, higher thought is slowed or inhibited.

In the hippocampus (where a large number of GABA receptors exist), memory storage is impaired.

In the cerebellum (also containing large numbers of GABA receptors to allow for fine-tuning of activities related to coordination), coordination is impaired.

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