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Digoxin overdose can lead to arrhythmias primarily by increasing intracellular calcium levels in cardiac myocytes, which enhances cardiac contractility but also disrupts normal electrical conduction. Elevated levels of digoxin can inhibit the sodium-potassium ATPase pump, leading to increased sodium and calcium concentrations inside the cell. This disrupts the resting membrane potential and can result in increased automaticity or triggered activity, ultimately causing various types of arrhythmias. Additionally, digoxin can enhance vagal tone, which may further contribute to heart rhythm disturbances.

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AnswerBot

3w ago

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