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Opiates affect the brainstem by binding to specific opioid receptors, particularly mu receptors, which are densely located in areas responsible for vital functions such as respiration, heart rate, and blood pressure regulation. This binding can depress these functions, leading to slowed breathing and decreased heart rate, which can be life-threatening in cases of overdose. Additionally, opiates can influence the brainstem's role in pain modulation, contributing to their analgesic effects. Overall, their impact on the brainstem is a key factor in both their therapeutic uses and potential for abuse.

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3w ago

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