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Assuming you're not talking about an allergic reaction, no, penicillin has a wide margin of safety and has not been associated with systemic toxicity.

Though you cannot overdose on penicillin, you could end up with severe diarrhea from taking too many at once.

Also, just because you have not had an allergic reaction before to a drug, taking too many could cause an allergic reaction.

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11y ago

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