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It depends on the stimulant. A good number are naturally occurring alkaloids found in plants. So all it takes is to process the plants and distill the chemicals from them. Caffeine, ephedrine, and cocaine are all naturally-occurring like this. Other stimulants are made from other chemicals, in a laboratory, including weaker stimulants. Pseudo-ephedrine is synthetic and chemically similar to to ephedrine. Methamphetamine ("meth") is made from pseudo-ephedrine and can probably be made from amphetamine.

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