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Codeine is converted by the liver into Morphine, which causes its pharmaceutical effects, Codeine itself it pharmaceutically inactive as it can't get into the brain. Morphine, like all Opioid painkillers causes the blood vessels to dilate and the blood pressure to drop. So Codeine will be perfectly safe for someone with normal or high blood pressure, but in people with low blood pressure extra caution should be taken when using Codeine.

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