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The drug Rompun (xylazine) has a half life in the horse of 50 minutes. So an hour after you have given a dose 1/2 of the amount given is still in the animals system the next hour 1/2 of that is gone so 1/4 of the original dose is still there the third hour you are down to 1/8th and the fourth hour down to 1/16. You can expect it to be completely cleared in 48 hours. Rompun should NEVER be given by anyone other than a veterinarian! It is NOT a tranquilizer, but and anesthetic/pre-anesthetic and can kill a horse very quickly if you do not know the signs of cardiac/respiratory distress and have yohimbine on hand to reverse the effects!NEVER allow anyone other than a qualified veterinarian or technician to administer this drug to your horse. Lately many farriers have been getting their hands on this drug instead of acepromazine because of its faster acting effects with some really disasterous results. Acepromazine does not effect the hematocrit (Blood oxygen content) when respiration is slower which is NOT true of xylazine.

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