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The elimination half-life of Dilaudid (hydromorphone) is typically about 2 to 3 hours, while Percocet (oxycodone and acetaminophen) has a half-life of around 3 to 4.5 hours. Generally, it can take about 5 to 6 half-lives for a drug to be cleared from the bloodstream, meaning Dilaudid may be detectable for around 10 to 18 hours and Percocet for approximately 15 to 27 hours. However, detection times can vary based on individual factors such as metabolism, dosage, and overall health.

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