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It depends on several factors, most importantly:

- Tolerance

- Body weight

- Body physiology

- Other drugs taken

Although Benzodiazepines are very safe when taken on their own in an overdose, some of the more potent Benzodiazepines can still be fatal in moderate dosages (though usually only with potent hypnotics such as Temazepam, Lormetazepam, Flunitrazepam, Nitrazepam, etc.) A fatal dose of Alprazolam taken on it's own can be anywhere between 100 and 1000mg, depending on the factors involved, and cause of death will likely be respiratory arrest.

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