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Death from drug intoxication can occur through several mechanisms, including respiratory depression, cardiac arrest, or organ failure. Central nervous system depressants, such as opioids or benzodiazepines, can slow or stop breathing, leading to hypoxia and death. Stimulants like cocaine or methamphetamine can cause fatal heart arrhythmias or stroke. Additionally, overdose can result in toxic metabolic effects, overwhelming the body's ability to function.

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