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Not necessarily. I've been on both, separate and in conjunction. Elavil (amitryptyline) is an old antidepressant with a lot of unpleasant side effects. Definatly not a clean drug. Vicodin (hydrocodone) is relatively clean, but still has undesirable side effects. It is very common for them to be prescribed together for pain management, therefore I don't think there is any actual interaction between the two. Adverse reaction would be due to one drug or the other. Assuming that you are concerned regarding the psychological effects of the two: Both drugs have euphoric properties, although different. Eight years ago when I was taking Elavil it was for migraines and always before bed. It always made me very tired and relaxed. Every morning I felt hungover and out of it, not in a good way. This lasted for about 5 hours. I had to stop taking it. I've been on Vicodin for almost 10 years for herniated disks (L4, L5, S1). It can make me feel energetic, social, and give an overall sense of well-being. Even though I know firsthand how dirty Elavil is I'm currently exploring the possibility of taking it again due to severe sciatica in which the Vicodin doesn't touch. Btw, if you take Elavil during the day you'll probably regret it. I did... Hope this helps and I hope if your taking medication for pain management you can find relief. Most of us (myself included) can't due to addicts abusing the system.

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