Is it safe to mix Adderall XR and seroquel?

Answer 1

The combination is perfectly safe - to put it very simply, Adderall and Seroquel are sort of like polar opposites - Adderall is an amphetamine, which acts as a stimulant by increasing the amount of Dopamine in the brain, whereas Seroquel functions to decrease the amount of Dopamine floating around in the brain. That's the super simplified version.

The expanded version:

Although it's a safe combination, it might not be a very effective combination, depending on your reason for using these drugs.

For AD/HD, the combination is fine, I will not go into details, but let's just say even though Seroquel is a 'downer' and Adderall an 'upper', the mechanism whereby Adderall supposedly produces its anti-ADD effect has to do with another sector, if you will, of Dopamine receptor sites, than the one which Seroquel acts upon to exert an anti-dopamine action. So you can take both for AD/HD, although some doctors will still not recommend it, since the exact mechanism whereby amphetamines manage AD/HD is not exactly understood, and since Seroquel is a downer which can be used to totally get rid of the stimulating effect of amphetamine, it is rational to assume that perhaps, taking Seroquel with Adderall at the same time, might not be a good idea, because Adderall will not act as a stimulant in this mix, and stimulation, according to many doctors, is essential to ADHD management and concentration...which Seroquel inhibits very effectively. Thus, my opinion is, the two drugs should NOT be taken together, because they basically cancel one another out, however I am not a doctor, I'm just someone who has tried this combination and found it to be completely ridiculous for reasons mentioned above. But everyone is different, and many doctors will disagree without knowing why, so keep that in mind.

If the Adderall is being taken for its CNS stimulating properties, as in narcolepsy management, or for its anorectic properties.....Seroquel should not be taken in this case, as both wakefulness-promoting and anorectic qualities of the amphetamine will completely be lost.