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I would recommend talking to your doctor if you are having pains which keep you up at night. The Benadryl in Tylenol-PM can react with Wellbutrin and cause increased side effects. They are not life threatening, but why risk it if you can talk to the doctor and figure out what's causing this problem. One of the early symptoms of depression is vague aches and pains - if that's what's going on, your doctor can adjust your wellbutrin dose.

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15y ago

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