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Naproxen is primarily metabolized in the liver through the cytochrome P450 enzyme system, specifically CYP1A2 and CYP2C19. However, a significant portion of the drug is excreted unchanged in the urine. While liver metabolism plays a role in its processing, the kidneys also play a crucial role in eliminating the drug from the body. Therefore, both organs are involved in the pharmacokinetics of naproxen.

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2w ago

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