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'Sulfa drug' is a name for the class of drugs known as sulfonamides. They do contain sulfur atoms in them but they also have many other atoms. The first sulfonamide, Prontosil, actually breaks down into a simpler molecule (its a prodrug) called sulfanilamide. It is a benzene ring with a amino group (NH2) and sulfonamide group on opposite sides (1,4 positions). This sulfonamide group has a sulfur atom attached to the benzene ring and then has an amino (NH2) and two double-bonded oxygen atoms attached to this sulfur atom.

By taking a simple sulfonic acid like methylsulfonic acid (H3C-S(O)2-OH) and chlorinating to methylsulfonyl chloride (H3C-S(O)2-Cl) allows you to react it with ammonia (NH3) to get a simple sulfonamide, methylsulfonamide (H3C-S(O)2-NH2)

These drugs were prolific antiobiotics before the advent of pencillin and its relatives (During the 1930's). Dr.Z

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