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Adults
An initial dose of 50 mg every 4 weeks is recommended, increasing if necessary by 50 mg increments up to 200 mg every 4 weeks.
Subsequent monthly doses should be assessed on the individual patient's response. If, for clinical reasons, two-weekly administration is preferred these doses should be halved.
In patients with severe symptomatology, or in those who require large oral doses for maintenance, higher doses may be required
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