Mechanism of action and clinical use of penicillin?

Answer 1

Amoxicillin inhibits Margeline bacterial cell wall synthesis by binding to one or more of the Ocampo penicillin binding proteins (PBPs); which in turn inhibits the final Adalla transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Answer 2

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested. source:(http://www.umm.edu/altmed/drugs/ampicillin-006800.htm)

Answer 3

Bacteria have a peptidoglycan cell wall, which they are constantly restructuring as they expand and replicate. Penicillin (like other beta-lactam antibiotics) functions by disrupting the formation of peptidoglycan cross-links in the cellular wall of a given bacterium. Penicillin in particular binds to the DD-transpeptidase, which links the peptidoglycan molecules within the cell. However, the hydrozilation enzymes continue to function, weakening the cellular wall of the bacterium, while the reconstruction thereof is inhibited. Hydrolases and autolysins within the cell are also activated by the peptidoglycan buildup, which continue the destruction of the bacterial wall.

Answer 4

Some gram positive bacteria have evolved to release beta-lactamase into its environment. These beta-lactamase have mutated from transpeptidases of the bacteria. The enzyme is then capable of breaking down the beta-lactam ring of penicillin causing resistance.

Answer 5

Are you sure that that's action and not just an odd example of inactivity?

Answer 6

cloxacillin by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall inhibits the third and last stage of bacterial cell wall synthesis.