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Nursing considerations include: * While not nearly as dangerous a respiratory depressant as other opioids or opiates, at high doses, this may be a consideration. * Tramadol is metabolized in the liver. Caregivers are cautioned to doublecheck for meds that inhibhit liver function, or watch for adminstration on hepatic compromised patients. * Tramadol lowers the seizure threshold. It also synergizes with SSRI's and tricyclics, and may have a stronger effect on epileptics. Ergo, seizure warning. Tramadol is about 10% as effective as MS when delivered IM/IV. As such, it does not have demonstrate the powerful anti-shock properties of MS.

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16y ago

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