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In the 1970s, several anti-nausea drugs were commonly used, including promethazine (Phenergan) and prochlorperazine (Compazine), both of which are phenothiazines. Another drug, metoclopramide (Reglan), was also utilized for its antiemetic properties. Additionally, antihistamines like dimenhydrinate (Dramamine) and diphenhydramine (Benadryl) were used for motion sickness and nausea. These medications primarily targeted nausea related to various causes, including motion sickness and postoperative effects.

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