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A good question. My experience is absolutely, as I became manic after becoming addicted to smoking, and then I used seroquel to treat my symptoms. However, after just a few days on a low dose (125mg) I woke up to smoke (my favourite time of the day) and the smoke tasted different, really bitter and I felt no buzz. In my experience, there is a direct counteractive effect, as nicotine contained in tobacco smoke increase dopamine NE and 5HT pathways, whilst seroquel shuts them down. I have just co-authored a paper that has been submitted in bipolar disorders (journal) on bipolar disorder and smoking. I am an honours level student in psychology to list my creditials.

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11y ago

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