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A potentially fatal drug reaction of codeine is respiratory depression. The higher the dose taken, the more likely it is for breathing, heart rate, and blood pressure to slow to dangerous levels. Codeine is absorbed quickly from the GI tract and its first pass through the liver results in very little loss of the drug. With chronic codeine use, the brain slows or even stops endorphin production resulting in the following side effects

  • Constipation, stomach bleeding
  • kidney and liver damage
  • Skin nodules and itching
  • nausea, hangover
  • tiny pupils, blurred vision, poor night vision
  • impair your ability to drive
  • lowered heart rate, blood pressure and breathing
  • disorientation, hallucinations
  • convulsions, depression
  • sexual dysfunctions
  • agitation, tremors, and seizures

The worst symptoms pass within a few days, but it can take months to feel normal.

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