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What are the drug interactions associated with ipriflavone that increases their effects?
Do not take ipriflavone with theophylline, azfirlukast, antipsychotics, caffeine, celecoxib, cyclobenzaprine, nifedipine, anti-inflammatories, pain relivers, tacrine, tamoxifen, warfarin.
How does the chemistry of ipriflavone effect drug interactions?
Ipriflavone has an inhibiting effect on a liver detoxification pathway involving an enzyme known as cytochrome P450. This effect increases both the blood levels and the effects of some drugs.
What is the recommended dosage of ipriflavone?
The recommended dosage of ipriflavone is 600 mg daily.
How is ipriflavone metabolized in the body?
The liver metabolizes ipriflavone into 7-hydroxy-ipriflavone and 7-(1-carboxy-ethoxy)-isoflavone. IP and its derivatives are bound to albumin, a blood protein, and distributed to tissues throughout the body.
How may gastrointestinal disturbances caused by ipriflavone be treated?
Gastrointestinal disturbances may be avoided by taking the ipriflavone supplement with food.
Which drug interactions are additive when taking ipriflavone?
The drug interactions that are additive when taking ipriflavone include bisphosphonates, calcitonin, estrogen, selective estrogen receptor modulators.
What is the difference between natural isoflavone supplements and ipriflavone?
Most soy isoflavones are classified as plant estrogens (phytoestrogens), ipriflavone does not have estrogenic activity, and does not activate any estrogen receptors in the body.
What are the precautions with using ipriflavone?
Ipriflavone may decrease lymphocyte levels. Not for those with liver disease, pregnancy/breast feeding, gastric or duodenal ulcers, kidney disease, small children.
Which nutritional supplements may cause an additive effect when taking ipriflavone?
The nutritional supplements boron, calcium, fluoride, vitamin D, vitamin K may have an additive effect when taken with ipriflavone.
How does ipriflavone treat medical condtions?
Ipriflavone prevents rapid bone loss, increases bone density, decreases bone fractures, reduces bone pain, increases mobility, lowers high cholesterol levels, some activity against cancer.
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