Renin
renin activates angiotensin in the blood
When the kidney detects low blood volume, it activates the renin-angiotensin-aldosterone system, leading to the release of renin, which converts angiotensinogen to angiotensin I, eventually converting to angiotensin II. Angiotensin II helps to constrict blood vessels, increase blood pressure, and stimulate the release of aldosterone, which promotes sodium and water retention to restore blood volume.
The primary chemical affected by the renin-angiotensin-aldosterone system is angiotensin II. This hormone is involved in regulating blood pressure and electrolyte balance by causing vasoconstriction and stimulating the release of aldosterone from the adrenal glands.
Angiotensin-converting enzyme (ACE) is an important enzyme in the renin-angiotensin-aldosterone system (RAAS) that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that helps regulate blood pressure by narrowing blood vessels. This enzyme is also involved in the regulation of fluid and electrolyte balance in the body.
Renin mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure. It activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE. Angiotensin II then constricts blood vessels, increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex, each leading to an increase in blood pressure.
Certain kidney disorders increase the production of angiotensin II, another cause of hypertension
They are medicines that block the conversion of the chemical angiotensin I
angiotensin
Angiotensin I is a peptide hormone that is a precursor to Angiotensin II, which plays a role in regulating blood pressure and fluid balance in the body. Angiotensin I is converted to Angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
No. Renin causes the blood pressure to rise. By low blood pressure the body releases Renin from the kidneys. Renin cleaves an inactive peptide, called Angiotensinogen, converting it to Angiotensin I. Angiotensin I is then converted to Angiotensin II by ACE (Angiotensin-Converting-Enzyme). Angiotensin II causes vasoconstriction and thus an increase in blood pressure.
Serum Angiotensin-Converting Enzyme (ACE) is an enzyme involved in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. It is also involved in the degradation of bradykinin, a vasodilator. Measurement of serum ACE levels can be used in diagnosing and monitoring certain diseases like sarcoidosis.
Urotensin II, Endothelin, Angiotensin II