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Ok, I'm assuming the antidepressants started in pill form and you crushed them up. Since they're a chemical and you're essentially burning them and turning them into smoke, and I'm guessing there's other material in with them like tobacco or something, I'd have to say they turn into something that's not particularly effective as an antidepressant - you're basically burning a carefully designed and produced chemical and inhaling the smoke from it. The results are likely to depend on how much you're using this way and what you're mixing it with - and I'm betting mostly the answer is going to be, it's gonna smell bad and do bad stuff to your lungs and not much good for your brain either.

Best to take the pills in pill form. With water or something. Setting them on fire is not likely to help.

Ussually, antidepressants dont come as pills but as capsules. In the case of Prozac, they come as a hydrochloride salt, which means they are pretty acidic. Snorting them is very painful, and I would imagine that smoking them could be very bad for your lungs

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