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First, be patient. Many antidepressants take 4-6 six to show signs of improvement while newer generation antidepressants such as Lexapro can show signs of improvement as early as one week. Sometimes antidepressants are working but the effects are subtle. Keep a daily journal of your mood and depressive thoughts (such as thoughts of suicide) to track your progress. If you do not show signs of improvement then talk to your doctor about switching to a different one. The process of finding an effective antidepressant and the effective dose of that antidepressant is sometimes so long and laborious that it is easy to lose track of signs of worsening or improvement. A combination of therapy and antidepressants will be the most effective.

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