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It is a radiation sensitizer

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14y ago

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What is Gemcitabine also called?

Gemzar


What is Gemzar also called?

Gemcitabine


When does the patent on Cymbalta expire?

Jun 11, 2013Lilly will also lose patent coverage for Humalog and Gemzar in 2013.


What is avastin?

Avastin is the latest chemotherapy medicine by Hoffman La Roche as of 2010 after Alimta. It is very expensive medicine for cancer treatment. It can be used with Cisplatin and Gemzar. But still it has very less success rate in 3rd stage of cancer (espacially lungs cancer). I must say that pharmaceutical company should not play with the lives. I mean to say that price should be low so that maximum people can afford it.


List of all drugs which cross blood brain barrier?

Drug ClassGeneric Name(Trade Name)AbsorptionDistributionElimination Alkylating Agentsmelphalon(Alkeran)oral - variably and incompletely absorbed from the GI tract, decreased in presence of foodmoderately high protein binding, Vz 0.5 l/kgdeactivated in plasma by hydrolysiscyclophosphamide(Cytoxan)oral - high bioavailability; intravenouscrosses blood-brain barrier (limited)hepatic biotransformation (includes activation); 5 - 25% eliminated unchanged (renal); parent and metabolites eliminated in urine are toxic to bladderifosfamide(Ifex)intravenous infusion onlyactive metabolites cross blood-brain barrier (limited)hepatic biotransformation (includes activation); 10 - 60% eliminated unchanged (increases with increasing dose - renal); parent and metabolites eliminated in urine are toxic to bladderbusolfan(Myleran)oral - completely absorbed from GI tractrapid hepatic biotransformationprocarbazine(Matulane)oral - Rapidly and completely absorbed from the gastrointestinal tract.Crosses blood-brain barrier.Hepatic biotransformation, very short elimination half-life. 70% renal elimination as metabolites.dacarbazine(Otic-Dome)Intravenous onlylimited access to CNS; low protein bindingExtensive hepatic biotransformation; 50% renal elimination (1/2 unchanged).Antibioticsdaunorubicin(Cerubidine)intravenous onlybody water, excluded by blood-brain barrierhepatic metabolism produces both active and inactive metabolites.daunorubicin or doxorubicin liposomes(Daunoxome or Doxil)intravenous infusion onlylimited to vascular fluid, animal studies indicate delivery to CNS; tissues selectively "acquire" liposomes.greatly reduced hepatic metabolism compared to un-encapsulated drugdoxorubicin(Adriamycin)intravenous onlyhigh protein binding; extensive uptake into many tissues, does not cross blood-brain barrierhepatic metabolism produces both active and inactive metabolites; tissue metabolism results in production of free radicals.idarubicin(Idamycin)intravenous infusion onlyextensive tissue binding of both native drug and metabolite; very high plasma protein bindinghepatic and extrahepatic metabolism to equipotent metabolite; elimination primarily biliary as active metabolite.plicamycin(Mithracin)intravenous infusion onlycrosses blood-brain barrier, concentrated in Kupffer cells, renal tubular cells and bone surfaceselimination is renalmitomycin (Mutamycin)intravenous onlydoes not cross blood brain barrierhepatic biotransformation, 10% eliminated in urine unchanged (% increases as dose increases)pentostatin(Nipent)intravenous onlycrosses blood-brain barrier (CSF concentrations ~10% of plasma concentrations within 24 hours). Low plasma protein bindinghepatic biotransformation, 30% - 70% eliminated in urine as unchanged drugmitoxantrone(Novantrone)intravenous infusion onlyrapid extensive distribution to tissues; high protein bindinghepatic; long half-life (due to tissue binding & slow metabolism); small fraction eliminated unchanged.dactinomycin(Cosmegen)intravenous onlydoes not cross blood brain barrierMinimal biotransformation; Elimination primarily biliary/fecal 50% unchanged (24 hours), another 10% unchanged in urine (24 hour); remainder of the drug is recovered within 1 week.Antimetabolitesfluorouracil(Adrucil)intravenous onlygood tissue penetration, crosses blood brain barrierhepatic metabolism produces 2 active metabolites and catabolism; respiratory elimination as carbon dioxide; 7 - 20% unchanged in urinecapecitabine(Xeloda)oral (pro drug)as for fluorouracilhepatic activation by conversion to 5 fluorouracil; elimination pattern as for 5 flurouracilfludarabine(Fludara)intravenous onlydistributed to whole body waterRAPIDLY dephosphylated in serum to 2-fluoro-Ara-A, then phosphorylated intracellularly to active compound. Elimination is renal, approximately 20% unchanged 2-fluoro-Ara-Amercaptopurine(Purinethol)oral - variably and incompletely absorbed from the GI tract (up to 50%)Crosses blood-brain barrier but poorly; low protein bindingHepatic metabolism for both activation and catabolism; degraded by xanthine oxidase; 7 - 40% eliminated unchanged.gemcitabine(Gemzar)intravenous infusion onlydistribution of active metabolite is limited by saturable process. Giving gemcitabine at an excess rate WASTES drug (eliminated intact before conversion).Intracellular metabolism (saturable) to active metabolites. Hepatic deamination to inactive uracil metabolite.Hormonal Oncologicstopotecan(Hycamtin)intravenous infusion onlygood tissue penetration, volumes approximately 2x body water, crosses blood brain barrierreversible pH-dependent hydrolysis to inactive moeity (low pH favors active compound), hepatic metabolism insignificant; 30% eliminated unchanged in urineleuprolide(Lupron)IM injection - 90% bioavailability; 1 month, 3 month and 4 month release formulationsdistributed to extracellular fluid volume; moderate (50%) protein binding.Metabolized to several inactive peptides. Less than 5% recovered as parent or pentapeptide metabolite.tamoxifen(Nolvadex)oral administration, bioavailability??Hepatic biotransformation with enterohepatic circulation. Prolonged elimination; Elimination primarily biliary/fecal, mostly as metabolitesMitosis inhibitorsetopside(VP16)oral - variable dose-dependent oral bioavailability (F decreases as dose increases); intravenousLow and variable into CSF, concentration differentials between normal and cancerous tissues. Very high protein binding (97%). Protein displacement interactions and hypoalbuminemia are concerns.Hepatic biotransformation; up to 50 - 60% renal elimination (2/3 as unchanged drug); remainder fecal.Othershydroxyurea(Hydrea)Well absorbed following oral administration.Crosses the blood-brain barrier (very small molecular weight).Hepatic metabolism (inactivation), 80% renal elimination within 12 hours (50% unchanged); balance eliminated from lungs as CO2paclitaxel(Taxol)intravenous onlyextensive extravascular distribution and/or tissue binding. Very high plasma protein binding.Hepatic p450 metabolism. Elimination primarily biliary / fecal. Variable renal elimination of unchanged drug.docetaxel(Taxotere)intravenous onlywidely distributed in tissues; slightly larger than body water; poor CNS penetration.Hepatic p450 metabolism. Elimination primarily biliary / fecal.cisplatin(Platinol)intravenous onlydoes not penetrate CNSrapid non-enzymatic conversion to inactive metabolites. Elimination usually expressed as recovered platinum (only 50% after 5 days), platinum detected in tissues for months.aspariginase(Elspar)intravenousintramuscularslow sequestration by reticuloendothelial system; poor CNS penetrationunknown pathway, only trace amounts appear in the urine following IV administration.Anti-toxicityamifostine(Ethyol)intravenous infusion onlywide rapid distributionmetabolised by alkaline phosphatase to active free thiol metabolite (binds cisplatin metabolites and alkylating agents and scavanges free radicals. Reaction favored in normal tissues (higher AP)dexrazoxane(Zinecard)intravenous onlydistributed to whole body water, low protein bindingseveral hepatic metabolites, intracellular metabolite may be responsible for action though this is speculative at this timemesna(Mesnex)intravenous onlyvolume of distribution approximates body water.rapid hepatic biotransformation to mesna disulfide; mesna disulfide is reduced to mesna by renal tubular epithelium, mesna binds and detoxifies metabolites of oxazophosphorines.I think it maybe useful for You :)


List of all drugs?

LSD cannabis Cocaine magic mushrooms hubbly bubbly heroine crack speed A hubbly bubbly is not a drug.Its slang for a 'Hookah' pipe, similar to that used for smoking tobacco in Arab countries. You need to look up Laws & Statutes Covering illegal drugs.


List all drugs?

coccine herione weed parcetamol caffine ecasty LSD magic mushrooms cannbis GHB poppers crystal meth Way More Hunny ^ -Oxy Contin -Zantex -Sidepack Mushrooms -Incents (Inhalent, Doesn't Show Up On Drug Tests, That's What I Did For Awhile) -Loripel -Acid -Tabacco (Yes, Tabacco Is, Infact A Drug.) And Many More Acctually. To Learn More, Go To The Fallowing... erowid.org Hope This Answered Ur Question (: