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The difference is in the chemical composition, one containing the SODIUM SALT. They are both nonsteroidal anti-inflammatory drugs.

Naprosyn (Aleve) is available over the counter and is indicated for the temporary relief of minor pain and inflammation., Naproxen sodium (Anaprox) is by prescription only (pharmaceutical strength) for relief of chronic pain and inflammation. Anaprox is almost the same formulation as Naprosyn, but in a fast-acting version of the drug. Both medications are NSAIDs that treat pain associated with menstruation. Each of these medications have ACTIVE contra-indications and side effects, so please review before taking any of the meds.

Naprosyn is manufactured by Roche Pharmaceuticals. Aleveis manufactured by Bayer Healthcare, previously Roche Pharmaceuticals. Anaprox is also distributed by Roche Pharmaceuticals.

The chemical names for naproxen (Naprosyn) and Naproxen sodium are (S)-6-methoxy-α- methyl-2-naphthaleneacetic acid and (S)-6-methoxy-α-methyl-2- naphthaleneacetic acid, sodium salt, respectively. Naproxen and naproxen sodium have the following structures, respectively:

naproxen (R=-COOH) C14H14O3 mol wt 230.26

naproxen sodium (R=-COONa) C14H13NaO3 mol wt 252.23

Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen sodium has a molecular weight of 252.23 and a molecular formula of C14H13NaO3.

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