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Nonsteroidal anti-inflammatory drugs,, are drugs with analgesic and antipyretic effects and which have, in higher doses, anti-inflammatory effects. The term "nonsteroidal" is used to distinguish these drugs from steroids, which have a similar eicosanoid-depressing, anti-inflammatory action.
Most nonsteroidal anti-inflammatory drugs are weak acids, with a pKa of 3-5. They are absorbed well from the stomach and intestinal mucosa. They are highly protein-bound in plasma (typically >95%), usually to albumin, so that their volume of distribution typically approximates to plasma volume. Most NSAIDs are metabolised in the liver by oxidation and conjugation to inactive metabolites which are typically excreted in the urine, although some drugs are partially excreted in bile. Metabolism may be abnormal in certain disease states, and accumulation may occur even with normal dosage.
Uses
a. Antipyretic, analgesic and antiinflammatory; especially good for pain of headaches, muscles and joints
b. Aspirin also has antiplatelet activity since it causes irreversible inhibition of both cyclooxygenases and platelets are not able to synthesize cyclooxygenase. Thus, until the next generation of platelets develops, which takes 8-11 days, platelet function is disturbed. This enables aspirin to be used for prophylactic treatment of coronary artery disease, thrombotic CVA Cardiovascular Accident and hypercoaguable states.
c. Topical use of salicylic acid irritates skin and mucus membranes and so is used in the treatment of warts, corns and some fungi.
d. Rectal suspensions and suppositories of mesalamine are useful in the treatment of inflammatory bowel disease. Sulfasalazine is ingested and in the colon breaks down to mesalamine.
What else can I help you with?
How do NSAIDs affect individuals with asthma?
NSAIDs (nonsteroidal anti-inflammatory drugs) can worsen asthma symptoms in some individuals by triggering bronchospasms and inflammation in the airways. It is important for individuals with asthma to consult with their healthcare provider before taking NSAIDs to avoid potential complications.
Are nsaids opioids?
No, NSAIDs are not opioids, but some opioids are formulated with NSAIDS in the pill.
How do NSAIDs affect tendon healing?
NSAIDs can potentially slow down tendon healing by reducing inflammation, which is a key part of the healing process. This can lead to delayed recovery and potentially worsen the injury. It is important to consult with a healthcare professional before taking NSAIDs for tendon injuries.
Can NSAIDs contribute to hearing loss?
Yes, NSAIDs (nonsteroidal anti-inflammatory drugs) can contribute to hearing loss as a potential side effect, especially with long-term or high-dose use. It is important to consult with a healthcare provider before taking NSAIDs regularly to discuss potential risks and benefits.
Can NSAIDs be taken while Breastfeeding?
Breastfeeding is not advised while taking NSAIDs
How are NSAIDs divided?
They are usually divided into the nonselective NSAIDs and the COX-2 specific agents
What are the recommended NSAIDs for treating tendonitis"?
The recommended NSAIDs for treating tendonitis are ibuprofen and naproxen.
What is the difference between aspirin and nsaid?
NSAIDs are a class of meds. Aspirin is one of many NSAIDs.
Common adverse reaction seen with nsaids?
dont get high off nsaids thats y god made narcautics. nsaids kill your liver and faster than any narcautic
Can taking too many NSAIDS cause hematuria?
Yes, taking too many nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to hematuria, which is the presence of blood in urine. Excessive use of NSAIDs may cause gastrointestinal bleeding or kidney damage, both of which can result in blood appearing in the urine. Additionally, NSAIDs can affect kidney function, potentially leading to conditions that contribute to hematuria. It's important to use these medications as directed and consult a healthcare professional if any unusual symptoms occur.
Are NSAIDs ototoxic and can they potentially cause damage to the ears?
Yes, NSAIDs (nonsteroidal anti-inflammatory drugs) have been associated with potential ototoxicity, which means they can cause damage to the ears and affect hearing. It is important to use these medications cautiously and consult a healthcare professional if you have concerns about their impact on your ears.
What are the potential risks and benefits of using selective NSAIDs for pain management?
Selective NSAIDs can provide effective pain relief with fewer gastrointestinal side effects compared to non-selective NSAIDs. However, they still carry risks of cardiovascular events and kidney damage, especially with long-term use. It is important to weigh the benefits of pain relief against these potential risks when considering their use for pain management.
