Permethazine is an antihistamine used primarily to treat allergy symptoms, motion sickness, and nausea or vomiting, particularly in postoperative settings. It works by blocking histamine receptors in the body, which helps alleviate symptoms like itching and runny nose. Additionally, it has sedative properties, making it useful for treating insomnia and anxiety in some cases. Permethazine is available in various forms, including tablets, syrup, and injections.