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What is straub test?

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Anonymous

∙ 16y ago
Updated: 11/16/2022

Morphine given intracerebroventricularly in mice produces a severe spasm of the anal sphincter(sacrococcygeus muscle) resulting in erection of the tail.This is mediated via activaion of supraspinal mu-opioid receptors and is inhibited by supraspinal kappa-opioid receptors. This test was formerly employed to detect morphine in biological fluids but many other compounds including methadone evoke a similar response.

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∙ 16y ago
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