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DEA Schedules of Controlled Substances The Controlled Substances Act of 1970 regulates the manufacturing, distribution, and dispensing of drugs that are known to have abuse potential. The Drug Enforcement Agency (DEA) is responsible for the enforcement of these regulations. The controlled drugs are divided into five DEA schedules based on their potential for abuse and physical and psychological dependence. Schedule I (C-I): High abuse potential and no accepted medical use (heroin, marijuana, LSD) Schedule II (C-II): High abuse potential with severe dependence liability (narcotics, amphetamines, and barbiturates) Schedule III (C-III): Less abuse potential than schedule II drugs and moderate dependence liability (nonbarbiturate sedatives, nonamphetamine stimulants, limited amounts of certain narcotics) Schedule IV (C-IV): Less abuse potential than schedule III and limited dependence liability (some sedatives, antianxiety agents, and non-narcotic analgesics) Schedule V (C-V): Limited abuse potential. Primarily small amounts of narcotics (codeine) used as antitussives or antidiarrheals. Under federal law, limited quantities of certain schedule V drugs may be purchased without a prescription directly from a pharmacist. The purchaser must be at least 18 years of age and must furnish suitable identification. All such transactions must be recorded by the dispensing pharmacist. Prescribing physicians and dispensing pharmacists must be registered with the DEA, which also provides forms for the transfer of Schedule I and II substances and establishes criteria for the inventory and prescribing of controlled substances. State and local laws are often more stringent than federal law. In any given situation, the more stringent law applies.

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