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Doxycycline hyclate and doxycycline monohydrate are both antibiotics used with other medicines to treat acne caused by bacterial infections. Both drugs are generic names of particular brand names, and that's the difference between them. The brand names used for doxycycline hyclate are Vibra-Tabs and Vibramycin. The brand names used for doxycycline monohydrate are Adoxa and Monodox.

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