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No difference, except in the naming. The active ingredient in Roxicodone is oxycodone, so essentially they are one and the same. Oxycodone is also found in Percocet, OxyContin, OxyFast, etc. Some of these meds are short acting, while OxyContin is a sustained release medication. Also worth mentioning is Roxicodone has no APAP, similar to OxyIR, and is often administered to chronic pain patients with liver problems.

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